Article publication date
January 2025
ARPANSA review date
26 February 2025
Summary
This systematic review evaluated the association between exposure to low dose ionising radiation (LDIR) and thyroid function among occupational populations. A total of 15 studies (6 case-control studies and 9 cohort studies) published between 1997 and 2022, which included a total of 1,040,763 participants, were included in the review. The effect on thyroid function were evaluated in terms of risk of thyroid cancer, thyroid nodules, and changes in thyroid hormones. Quality assessment of the included studies was also conducted according to the Newcastle-Ottawa Scale (NOS). A qualitative evaluation of the studies was conducted to assess the effect of LDIR on thyroid function. The review showed some evidence of increased thyroid gland volume and nodule formation following the exposure to LDIR, however, this was not shown with certainty. The studies showed a reduction in triiodothyronine (fT3) and an increase or reduction in thyroxine (fT4), while thyroid stimulating hormone (TSH) level did not change following the exposure. Based on the analysis in the review, the authors conclude that even at low doses the function of the thyroid is negatively affected.
Published in
Journal of Clinical Medicine
Link to study
Low-Dose Ionizing Radiation and Thyroid Diseases and Functional Modifications in Exposed Workers: A Systematic Review
Commentary by ARPANSA
This review provides an evaluation of whether thyroid function changes following occupational exposure to LDIR. The findings indicate that exposure to LDIR may be a potential risk factor for some aspects of thyroid function. The study shows a few strengths and limitations, which should be considered while interpretating the findings of the review. The review presents only a narrative synthesis of results evaluating multiple health outcomes of thyroid gland e.g., cancer, nodules, and hormones in relation to LDIR exposure; and quantitative meta-analyses of the included studies were not conducted. The cohort studies included in the review had a relatively large sample size.
The quality assessment of the included studies showed moderate quality, however, the review did not conduct a risk of bias (ROB) assessment of the included studies. ROB assessment has been regarded as an essential critical step in a systematic review to inform the findings and interpretation of the review (NHMRC, 2019). It should be noted that the NOS quality assessment involves the evaluation of the extent to which included studies were designed, conducted, analysed, and reported to avoid systematic errors; while ROB assessment involves the evaluation of bias judgments based on the quality assessment (Furuya-Kanamori et al., 2021). The review also did not undertake a certainty in evidence assessment, which is another important aspect of a properly conducted systematic review. Similarly, although the included studies represent some heterogeneity, it was not assessed in the review. For example, the included studies were conducted in diverse occupational setting (e.g., hospital, nuclear power plants, war industry, and barracks) where the approach to collecting workers’ data would have been different. The findings highlighted in the review are consistent with some comparable studies (e.g., Gudzenko et al., 2022; El-Benhawy et al., 2022; Cioffi et al., 2020). However, there are no similar data available to compare these findings in the Australian context. It is unclear if the review accounted for potential differences in calculating the dose to the thyroid; for example, changes in radiation weighting factors (e.g., ICRP60 to ICRP103), changes in dose conversion factors (e.g., ICRP68 to ICRP137) or inference of thyroid doses based on whole body monitoring. It is our assessment that there is insufficient evidence within this review to definitively conclude that thyroid function is adversely affected by LDIR.
In Australia, The Code for Radiation Protection in Planned Exposure Situations sets out the requirements for the protection of occupationally exposed persons in all planned exposure situations. All Australian jurisdictions have uniform annual limits (20 mSv) for occupational exposure to ionising radiation. In addition to the dose limits, optimisation of radiation protection and safety involves practising ‘as low as reasonably achievable’ (ALARA) considering economic and societal factors. The Australian system for radiation protection from ionising radiation is closely aligned with international best practice as laid out in the Recommendations of the International Commission on Radiological Protection.