The radiation literature survey provides updates on published literature related to radiation (both ionising and non-ionising) and health.

Published literature includes articles in peer-reviewed scientific journals, scientific-body reports, conference proceedings, etc.

The updates on new radiation literature that are of high quality and of public interest will be published as they arise. For each update, a short summary and a link to the abstract or to the full document (if freely available) are provided. The update may also include a commentary from ARPANSA and links to external websites for further information. The links may be considered useful at the time of preparation of the update however ARPANSA has no control over the content or currency of information on external links. Please see the ARPANSA website disclaimer.

Explanations of the more common terms used in the updates are found in the glossary.

The radiation literature that is listed in the updates is found by searching various databases and is not exhaustive.

Find out more about how you can search for scientific literature.

The intention of the radiation literature survey is to provide an update on new literature related to radiation and health that may be of interest to the general public. ARPANSA does not take responsibility for any of the content in the scientific literature and is not able to provide copies of the papers that are listed.


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Study reviews the risk of cancer following low and moderate estimated doses of ionising radiation in early life

Authored By:

Little et al.
Summary:

This paper reviewed studies on the risk of cancer or benign neoplasms following low or moderate doses of ionising radiation in utero or in childhood from medical and environmental sources. The literature search identified 60 studies that were included in this review and meta-analyses were conducted. The review found excess cancer risks associated with both in utero and childhood exposures. For childhood exposures this occurred at low radiation dose levels of less than 0.1 Gy, and for in utero exposures this occurred at levels around 0.02 Gy. This review was mainly focused on leukaemia but also found evidence of an increased risk in brain/central nervous system cancers, as well as thyroid cancer. The authors conclude that childhood cancer risk is increased in the low radiation dose range of less than 0.1 Gy. These findings are further supported by a separate review conducted by Little et al. on medical diagnostic radiation exposure in early life without quantitative estimates of dose which reached a similar conclusion (a review of this study by ARPANSA can be accessed here).

Published In:

Environment International
Commentary by ARPANSA:

Moderate and high doses of ionising radiation at high dose rates are known to be associated with an increased risk of cancer. However, this review presents evidence of an increased risk of cancer at low radiation doses (less than 0.1 Gy). Special concern in relation to radiation protection is afforded to children, and women of child-bearing age with most diagnostic radiology procedures posing little risk to the mother or foetus. The Code for Radiation Protection in Medical Exposure (2019) (RPS C-5) sets out the Australian requirements for the protection of patients, including pregnant women and children, relating to their exposure to ionising radiation. While the (Little et al) study’s meta-analysis supports a statistically significant increase in cancer risk for low radiation exposure, the increase is very small, and the risks should be assessed against the benefits of having the procedure. ARPANSA advises parents concerned about their children’s exposure from radiological procedures to talk to the doctor requesting the radiological procedure. The child’s doctor and the staff at the radiology facility should work together on which tests are required and evaluate the risks and benefits in each child’s individual circumstances. If there are still questions at the radiology facility, these can be raised with the radiology team during the consent process before the imaging proceeds.

Is exposure to extremely low frequency magnetic fields (ELF-MF) and electric shocks associated with malignant lymphoma?

Authored By:

Jalilian et al.
Summary:

This nested case-control study evaluated the association between occupational exposure to extremely low frequency magnetic fields (ELF-MFs) and electric shocks and risk of lymphoma within the Nordic Occupational Cancer Cohort of Nordic populations (Finland, Iceland, Norway, Denmark and Sweden). The study included: cases of non-Hodgkin’s lymphoma (NHL, n=68,978), chronic lymphocytic leukaemia (CLL, n=20,615) and multiple myeloma (MM, n=35,467) diagnosed during 1961 – 2005. Each case was matched to five controls by year of birth, sex and country. Occupational exposure to ELF-MF and electric shocks was assessed using job-exposure matrices. The results of the study demonstrated no increased risks of these cancers among workers exposed to high levels of ELF-MF for NHL (Odds ratio (OR): 0.93; 95% confidence interval (CI) 0.90 – 0.97), CLL (OR: 0.98; 95% CI 0.92 – 1.05) or MM (OR: 0.96; 95% CI 0.90 – 1.01). Similarly, no increased risk of these cancers was reported for exposure to electric shock in occupational workers as the ORs were 0.94 (95% CI 0.91 – 0.97) [NHL], 0.93 (95% CI 0.87 – 0.99) [CLL], and 0.97 (95% CI 0.93 – 1.02) [MM]. The authors concluded that the study found no evidence of an association between occupational exposure to ELF-MFs and electric shocks and lymphoma risk.

Published In:

Occupational and Environmental Medicine
Commentary by ARPANSA:

Unlike some previous studies, including an Australian study, showing a mild association between occupational exposure to ELF-MFs and the risk of NHL in a few occupational groups, this latest study demonstrates no association. Compared to most of the previous study designs, this study adopted improved methods (e.g., inclusion of a larger number of cases, ascertainment of cases accurately and with nearly complete follow-up of study participants) to investigate this potential relationship. Therefore, the results of this current study provide improved reliability with reassuring findings of no risk. There seems to be a knowledge gap regarding whether occupational exposure to electric shocks increases the risk of lymphoma. This study presents the first evidence of no elevated risk of the disease associated with the exposure to electric shocks. Consistent to current international scientific consensus, it is the assessment of ARPANSA that there is no link between occupational exposure to ELF-MF and any cancer, including those investigated in this study.

Is Mobile Phone Radiation a Risk Factor for Headache?

Authored By:

Farashi et al.
Summary:

This systematic review and meta‑analysis, which included 30 eligible studies, assessed the relationship between exposure to mobile phone radiofrequency (RF) radiation and headaches in humans. The results showed that RF exposure from mobile phone base stations was not associated with headache, with Odds ratio (OR) of 1.14 (95% CI 0.75, 1.52). However, the authors did report that RF radiation emitted from mobile phones was associated with headaches, OR = 1.30 (95% CI 1.21–1.39). This risk was similar for younger people and adults and also for longer or shorter durations of mobile phone use. The authors concluded that RF radiation from mobile phones was associated with headaches. 

Published In:

International Archives of Occupational and Environmental Health
Commentary by ARPANSA:

Overall, this study reports that exposure to mobile phone RF radiation increases the risk of headache by up to 41%. Though the finding is in line with that of a previous systematic review and meta-analysis report (Wang et al., 2017), the results of these systematic reviews and meta-analyses should be interpretated cautiously. For example, the latest report only included three good quality studies, whereas most of the other included studies were either poor or fair quality. The quality of the study is also related to how well RF exposure to mobile phone was measured (e.g., self-reported vs quantitatively measured) and/or whether or not potential confounders were accounted for. For example, almost all studies included in the report employed self-reported RF exposure, which is only a substitute measure of actual RF exposure and hence likely to be inaccurate. The self-reported data on mobile phone use employed by most of these studies generally gives rise to error (i.e., recall bias) in RF exposure estimation. This, together with possible confounders unadjusted for in the studies, affects the potential relationship between mobile phone RF exposure and headache. These important methodological issues indicate that the review and meta-analysis process was not of good quality and likely resulted in providing biased findings.

It is the assessment of ARPANSA and international organisations such as The World Health Organisation (WHO) and The International Commission on Non-Ionising Radiation (ICNIRP) that there is no established scientific evidence to support that RF exposure when using a mobile phone causes headache. 
 

Evaluation of radiofrequency exposures to mobile phone base stations, Wi-Fi and Bluetooth in 13 countries

Authored By:

Boussad et al.
Summary:

This longitudinal study assessed radiofrequency (RF) radiation population exposure in 13 countries, including Australia. A mobile phone-based tool (Electrosmart™ App) was used to collect data on 254,410 mobile phone users’ downlink RF exposure (i.e. received radio signal strength) to mobile phone base stations, and Wi-Fi/Bluetooth networks over the period of three years (2017 to 2020). The study showed that Wi-Fi and Bluetooth contributed most of the total measured RF population exposure; and the exposure to these sources seemed to increase over time. However, the exposure levels recorded were orders of magnitude lower than regulation limits in each of the countries.

Published In:

Environment International
Commentary by ARPANSA:

Overall, the paper reported that the measured RF exposure levels were much lower than the Australian and international public exposure limits. Of note, the study methodology utilised to ascertain population RF exposure is not quite accurate as the App, in fact, measured the background downlink RF exposure. Further, it provides no information on how the measured background RF exposure represented the population RF exposure. In order for the measured background RF exposure to be represented as the ‘population exposure’, the study participants (i. e., mobile phone users) should place the phone close to the body during the whole time when RF exposure was measured. Therefore, the reported RF exposure can only be a surrogate measure of population exposure and hence, the findings of this study should be carefully interpreted. 

ARPANSA has conducted RF measurement studies around mobile phone base stations and published the results on the ARPANSA website. In 2017, ARPANSA published a study assessing the RF exposure level due to Wi-Fi in Australian schools. Exposure levels from other RF sources such as mobile phone base stations, radio, and TV broadcasts were also measured. Overall, the exposure levels from all RF sources measured were much lower than the public exposure limits in the Australian RF Standard. There remains no substantiated scientific evidence that exposure to RF EMF below the limits in the Australian RF Standard causes any adverse health effects. 
 

The UK Million women study shows no risk of brain tumours from mobile phone use

Authored By:

Schüz et al
Summary:

The UK Million Women Study is a prospective cohort study examining the association between mobile phone use and brain tumours in women. The study initially recruited 1.3 million women born from 1935 to 1950. Between 2001 and 2013, 776 156 women completed surveys on their mobile phone use every 3-5 years. Of these, 489 769 women reported using a mobile phone. The study found no overall increase in the risk of brain tumours in women using mobile phones compared to women that never used one (risk ratio 0.97, 95% confidence interval = 0.90 to 1.04). Furthermore, the study also found no risk of brain tumours among mobile phone users when assessed by brain tumour subtype, different levels of mobile phone use or duration of use for at least 10 years. The authors concluded that the use of mobile phones does not increase the risk of brain tumours in women. 
 

Published In:

Journal of the National Cancer Institute
Commentary by ARPANSA:

The results of this study are consistent with the results of a similar study and the only other prospective cohort study that has examined the association between mobile phones use and brain cancers, the Nationwide Danish cohort study. The Danish study divided the entire adult population of Denmark aged 30 and older into two groups - those who had a mobile phone subscription between 1990 and 2007, and those who didn’t. The Danish study reported no association between having a mobile phone subscription and brain tumour risk, even after at least 13 years of subscription. Similar findings were reported by an Australian study (a population-based ecological study) which found no increase in the incidence of brain tumours during 1982 to 2013. During this time there was a large increase in the number of mobile phone subscriptions in Australia (Karipidis et al, 2019). 

New review on cancer risk of medical diagnostic radiation exposure in early life without quantitative estimates of dose

Authored By:

Little et al.
Summary:

This paper reviewed studies on cancer risk from medical diagnostic radiation exposure in utero, and postnatal stages of life where radiation quantitative dose estimates were not available. The type of procedure (e.g. fluoroscopy, CT scan, X-ray etc.) gives a general indication of the likely dose involved but this is not as informative as studies that include data on the actual doses received. The literature search identified 89 eligible studies that were included in this review and meta-analyses were conducted. This review found multiple studies that yielded statistically significant excess cancer risks due to in utero and postnatal exposure to medical diagnostic radiation. Significantly higher risk estimates were found for leukaemia, lymphoma, central nervous system (CNS) tumours and any other cancer in the meta-analysis for in utero exposure. This is mainly due to earlier studies which found more significant excess risk than later studies. The reduced excess risk in later studies could be explained by the progressive decrease in foetal dose per X-ray examination due to advances in radiographic technology. For postnatal exposure, significant excess risks were more apparent in later studies, particularly CT scan studies. The postnatal meta-analysis found statistically significant excess risks for leukaemia, CNS tumours and any other cancer outcomes. This data strengthens the evidence for a carcinogenic effect of low dose radiation exposure in utero. However, the interpretation of the postnatal exposure findings is more difficult due to the possibilities of reverse causation (i.e. conditions predisposing to cancer lead to an increase of radiation imaging) biasing the results. Subsequently, this reduces the strength of a causal interpretation for postnatal exposure.

Published In:

Science of the Total Environment
Commentary by ARPANSA:

In Australia, the system for radiological protection draws on international best practice, particularly, the International Commission on Radiological Protection (ICRP) and the International Atomic Energy Agency (IAEA). Special concern in relation to radiation protection is afforded to children, and women of child-bearing age. Most diagnostic radiology procedures pose little risk to the mother or foetus. However, interventional radiology procedures, and CT scans of the abdomen or pelvis may result in an elevated foetal dose, and an increased risk of cancer. With the continuing advancement of the use of ionising radiation in medicine, it is important that safety guidance represents contemporary best practice. The Code for Radiation Protection in Medical Exposure (2019) (RPS C-5) sets out the Australian requirements for the protection of patients, including pregnant women and children, relating to their exposure to ionising radiation. It is ARPANSA’s goal to ensure that the highest standard of protection is made available through the implementation of the relevant Codes and Safety Guides. These safety materials give practitioners in diagnostic and interventional radiology a best practice approach to their day-to-day clinical work. While the (Little et al) study’s meta-analysis supports a statistically significant increase in cancer risk, the increase is very small and the risks should be assessed against the benefits of having the procedure. ARPANSA advises parents concerned about their children’s exposure from radiological procedures to talk to the doctor requesting the radiological procedure. The child’s doctor and the staff at the radiology facility should work together on which tests are required and evaluate the risks and benefits in each child’s individual circumstances. If there are still questions at the radiology facility, these can be raised with the radiology team during the consent process before the imaging proceeds. 

New study shows that electromagnetic fields don’t cause EHS symptoms

Authored By:

Huang et al.
Summary:

This is a human randomised crossover provocation study that investigated whether electromagnetic fields (EMF) exposure is associated with physiological changes and symptoms. The study recruited 58 participants with self-reported idiopathic environmental intolerance attributed to EMF (IEI-EMF) and 92 participants without IEI-EMF as a control group. In a double-blind controlled environment, participants were exposed to EMF signals mimicking those from a mobile phone base station and a sham exposure in a random sequence. Participants reported whether they could perceive EMF exposure and any symptoms they were experiencing while physiological parameters (heart rate, blood pressure etc.) were monitored. The IEI-EMF and control groups reported similar frequencies of symptoms during both the provocation and sham sessions. In both groups, physiological parameters were similar between the two sessions and no participant could accurately detect the presence of EMF. The results of this study indicate that radiofrequency EMF exposure from mobile phone base stations did not affect physiological parameters in people with or without IEI-EMF and that symptoms reported by participants were not related to EMF exposure.

Published In:

Environmental Health
Commentary by ARPANSA:

IEI-EMF, also referred to as electromagnetic hypersensitivity (EHS), has no clear diagnostic criteria and the science so far has not provided evidence that EMF exposure is the cause. The majority of scientific studies published to date, as well as this study, have found that under controlled laboratory conditions, EHS or IEI-EMF individuals cannot detect the presence of EMF sources any more accurately than non-EHS individuals. Several studies have indicated a nocebo effect (Van Moorselar et al. 2016; Verrender et al. 2018).  

Based on current scientific information, there is no established evidence that EHS symptoms are caused by exposure to EMF. However, ARPANSA acknowledges that the health symptoms experienced by the affected individuals are real and can be a disabling problem and advise those affected to seek medical advice from a qualified medical specialist. ARPANSA will continue to review the research into potential health effects of exposure to EMF to provide accurate and up-to-date advice.

More information on EHS is available in a factsheet by ARPANSA as well as the World Health Organization.
 

Review of radiofrequency heating and burn injuries caused by magnetic resonance imaging

Authored By:

Tang and Yamamoto
Summary:

This review describes the current progress in understanding radiofrequency (RF) heating effect and injuries, particularly burns, that have occurred in patients during magnetic resonance imaging (MRI) procedures. MRI scans are produced by applying a strong static magnetic field, a fast-varying magnetic field gradient, and a RF field. While MRI injuries remain rare, the frequency of accidents is increasing in parallel to the increasing application of high magnetic field strength. RF burn injuries constitute nearly half of all MRI related injuries and are increasing. RF burn injuries occur either due to skin to skin contact or skin contact with a wire/cable or a wire acting as an antenna that interacts with the RF field of the MRI machine. Considerable local heating occurs that is concentrated at the contact points of the wire or skin, however, the mechanism for some of the RF burn injuries occurring at contact points is not well understood. This poses challenges for the application of adequate safety or preventive measures for RF related burns in MRI procedures.

Published In:

Magnetic Resonance in Medical Sciences
Commentary by ARPANSA:

The review provides state-of-the-art knowledge on RF heating and burn injuries in medical MRI systems, including RF exposure limits. Internationally, the RF exposure limits for MRI procedures are guided by the recommendations of the International Commission on Non-Ionizing Radiation Protection (ICNIRP). These RF exposure limits are given in terms of specific absorption rate (SAR in W/kg), which is essentially the amount of RF energy absorbed per unit mass of human tissue. SAR limits applicable for the use of passive implants (e.g., hip and knee prostheses) or active implantable medical devices (e.g., cardiac pacemakers or cochlear implants) have been documented in other standards such as ASTM-F2182 and ISO/TS 109474:2018, respectively. 

The review also recommends key preventive measures to avoid the likelihood of RF related burns in MRI procedures. The recommendations include the use of foam pads (1-2 cm thick) to insulate the patient from cables, the bore, and between limbs to prevent RF burn injuries, avoiding positioning the body near the RF transmit coil and considering the antenna effect for patients with large implants and tattoos. These recommendations are consistent with those provided by the Royal Australian and New Zealand College of Radiologists (RANZCR).

In conclusion, this review is a useful guide to understanding MRI related RF burn injuries in medical imaging settings. 
 

Review on the impacts of electromagnetic fields on pregnancy and other health outcomes

Authored By:

El Jarrah & Rababa, Feb 2022
Summary:

This review aimed to investigate the possible link between exposure to electromagnetic fields (EMF) and adverse pregnancy outcomes and various other health effects. The authors state the review included all studies on the impacts of EMF from electronic devices on health outcomes among adults, pregnant women, and newborns or in non-human subjects or in vitro research published in the last 5 years. Based on this inclusion criteria the authors assessed 18 papers for the review. The authors concluded that EMF radiation is linked to various health effects and suggested women and children are at risk due to exposure during pregnancy.

Published In:

Heliyon
Commentary by ARPANSA:

There are a number of methodological issues with this review that indicate the authors have not fully assessed the evidence and may have omitted evidence contrary to their desired conclusions. Although the authors mention that they conducted a systematic review and describe in the methods how it was conducted, the results do not indicate a properly conducted systematic review. Although the studies are given a risk of bias (RoB) rating the full RoB analysis is not presented and it is noted that the authors rate poor quality studies as being high quality. Also, systematic reviews only include original research papers, but Al-Jarrah and Rababa include a meta-analysis in the final list of included studies [Tsarna et al, 2019]. There was also no formal synthesis of results presented. Further, the authors mix in vitro, in vivo, epidemiological, and human experimental studies which would require separate systematic reviews. Instead, the authors present a biased narrative review. 

The authors only assessed papers published in the last 5 years and there is no justification for the selection of this timeframe. This is a major source of bias as it excludes many modern high-quality papers on EMF and health. This short time frame for inclusion again highlights how the authors have ignored evidence on this topic. Additionally, the screening process as reported is flawed. The authors reportedly found 10,450 articles from 7 databases and yet only 311 articles remained after duplicates were removed meaning 10,139 articles were duplicates. This cannot be correct. Furthermore, the search strings used for each database search are not presented, nor is the number of articles retrieved from each database.

The authors’ assessment of pregnancy outcomes included nine papers. Of these, eight had clear limitations in their methods, particularly when assessing exposure that would prevent any causal association being made, and the other paper was a measurement study that was not assessing health outcomes. The authors of this review seem to have ignored these limitations when assessing the evidence of the included studies. 

Overall, this review by Al-Jarrah & Rababa failed to fully or adequately assess the available evidence on the impact of EMF on health and pregnancy outcomes. It also relied on papers with low quality methods and poor exposure assessment. Another recent review by Ashrafinia et al (2021) of higher quality studies assessed the impact of mobile phone exposure and adverse maternal, infant and child outcomes and reported no substantiated evidence of an impact from mobile phone exposure. It appears that the authors have “cherry picked” articles that suited their narrative and ignored or rejected papers that didn’t, as studies that did not find an association included in the Ashrafinia et al review were not included in this review despite being within the dubious 5-year timeframe. The particular papers that have been inexplicably excluded from the Al-Jarrah & Rababa review but are present in the Ashrafinia et al review include Sudan et al (2016), Papadopoulou et al (2017), and Choi et al (2017). Furthermore, a major review by the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) published in 2015 also found no substantiated evidence of a health impact from EMF exposure [SCENIHR, 2015].

Association between occupational exposure to solar ultraviolet radiation and skin cancers: The WHO systematic review and meta-analysis

Authored By:

World Health Organisation, December 2021
Summary:

This systematic review and meta-analysis assessed the associations between occupational exposure to solar ultraviolet radiation (UVR), and melanoma and non-melanoma skin cancer (NMSC). The results were based on data extracted from 53 eligible studies that involved over 457,000 participants in 26 countries. In most studies, the exposure to solar UVR was self-reported in questionnaires (e.g., during interviews), whereas the health outcome of skin cancers was based on histopathological diagnoses. The results showed that compared to non-exposed people, occupationally exposed UVR workers were 1.45 times and 1.60 times more likely to have melanoma and NMSC, respectively. Of NMSC subtypes, the risk of the incidence of squamous cell carcinoma was much higher (Risk Ratio 2.42) compared to that of basal cell carcinoma (Risk ratio 1.50). The report concluded that considering methodological limitations, such as bias and confounding, there is limited evidence for an association between occupational exposure to UVR and skin cancer. 

Published In:

The WHO website
Commentary by ARPANSA:

Although the report concluded that there is overall limited evidence for an association between occupational UVR exposure and skin cancer, the results support the current sun protection recommendations of national (e.g., Cancer Council Australia Sun safety | Cancer Council) and international (International Agency for Research on Cancer, IARC) organisations. The  IARC classifies solar UVR as a Group 1 carcinogen (IARC, 1992). Skin cancer accounts for the largest number of cancers diagnosed in Australia each year (Australian Institute of Health and Welfare, 2016). ARPANSA recommends that all people including workers should limit their UVR exposures, and a combination of sun protection measures (e.g., clothing and sunglasses, shade and sunscreen) should be used, wherever applicable. For more information see the ARPANSA factsheet, Sun exposure and health

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